Effingham is a city in Effingham County, Illinois, United States, and its county seat. It is in South Central Illinois. Its population was 12,252 at the 2020 census. It is the principal city of the Effingham micropolitan statistical area.
The city bills itself as "The Crossroads of Opportunity" because of its location at the intersection of two major Interstate highways: I-57 running from Chicago to Sikeston, Missouri, and I-70 running from Utah to Maryland.
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